I would theorize, as it hasnt really happened to me, but i have seen massive pressure drops and injector failures on customers trucks at the same time, that it would be thre pressure differential scenario which would possibly cause that. However, that being said, you will likely see a drop in pressure, or a bouncing gauge. But keep in mind as well, that a dirty filter will cause excessive strain on the pump, thereby shortening its life as well. Also, with ulsd, as much lubrication, ie fuel, as possible fed to the injectors wlll help them live happy lives. Ulsd is not as much of a lubricant as lsd, which is why the 6.4 had so many injection pump issues, it has been theorized, as they only run 3-6 psi to thi hpfp.