Lol. Many failures is what I meant to say. Ever since they took the sulfur out of diesel fuel the lubrication has went way down. I see it first hand in my dads shop. Big trucks and light diesels.
Engines not designed to run on ULSD have really been hit hard when everything was switched over. Old fuel pumps, lines, etc were all designed around the lubricating sulphur in diesel.
Sulfur has nothing to do with lubricity. Sulfur is not even a lubricant.
The manufacturing process used in the U.S. to produce diesel fuel strips most of the natural lubricity out. Fuel companies have been required to put additives in diesel fuel to supplement lubricity to meet federal and manufacturer requirements.
Here's what most people don't realize..... this has not been limited to ULSD. This has been going on for decades and decades now.
Modern diesel engines run just fine with diesel fuel that meets federal requirements. Now with that said, is it possible to get diesel fuel that doesn't meet minimum lubricity requirements? Of course. This is where using cetane booster can help, and just about any manufacturer will mention such products in the owner's manual.
So it won't hurt anything to run cetane boost. It's a fairly safe "what-if" in case you get diesel that doesn't have the proper additive pack put in from the fuel company.
However, there is nothing you can run that will protect from bad fuel. If you get bad fuel and the contaminates get past the filters, it can cause catastrophic damage. No bottle on the market will prevent such issues. Yet this is where the vast majority of fuel related failures happen.
It's almost impossible to find a truck that has had a failure due to not running cetane boost. That would require constant fill up of sub-standard fuel for years before it becomes a problem. Hence why running fuel additives are not a requirement for manufactures in terms of honoring warranty repairs.
In short... cetane boost/anti-gel is fine. There are many good products out there. Is it required? No, and most likely it won't actually provide substantially measured results in terms of engine longevity.
Anything else such as alternative fuel additives, oil additives, etc.... snake oil. Don't waste your money.