The primary reason we no longer offer the AD2 pumps is reliability, with ability to maintain enough volume/pressure second. You can only take so many calls from angry customers that are stuck on the side of the road before you just walk away. We did have several of them supporting good size injectors in both 7.3L and 6.0L trucks, when they were running and were setup properly.
I'm currently doing some testing on another setup, with 200/200s. Just got the truck running and still need to dial in the tuning before we do any WOT pressure testing. This will be a long term test though, because reliability is a factor as well.
With ANY type of pump that has a built in regulator (AD2 or FASS for example), I HIGHLY RECOMMEND NOT trying to use the pump as the only regulator in the system. It makes no sense regulating the pressure that far before the engine. The pressure at the pump will not accurately reflect the pressure at the injectors. You are always best having the pressure regulation after (but as close as possible to) all of the pressure drop and all of the "demand" (injectors).
Twin stock pumps is a great way to go for high reliability. The stock Bosch pumps are darn near bulletproof, designed and rated for diesel fuel use (unlike the Walbro), quiet, small, etc. These setups have been done for years with great success, and it's been on my "to do" list to build a clean dual stock pump setup forever...but other crap keeps getting in the way. The biggest downside to this setup is that the pumps are not inexpensive, and they don't have changeable inlet fittings (no clean way to attach "AN" style hoses). They also have very small outlet threads with a limited availability of fittings unless you connect adapters to adapters. It makes doing a "clean" (by my definition...if you've seen how we do other things you'll understand) setup a bit tough.
As for AirDog/FASS type pumps in other applications...in my experience they both work best in applications where they are operating as "HIGH VOLUME / LOW PRESSURE" pumps. My race truck has an AD150 running at 10psi feeding the Fuelab pump. The Fuelab pump handles the high pressure duties and the whole system is managed by the Regulated Return setup. I get the filtration and air removal of the AirDog and the high pressure capability of the Fuelab...and they both do their job well. It's a bit more expensive to run it this way, but it works great and the pressure is solid, even with 400cc injectors.
Also, running fuel into the rear fittings on the heads is not necessary. I'm supporting 400s through the 1/8" ports, the old WOP OBS as well as the Lightning and Dragster were both plumbed the same way last time I looked too. Food for thought...