OP, I told you temps will be dependent on your right foot !
They are nothing to worry about as far as drivability. I cruise around 750* on the highway at about 2k with 0-2lbs boost and 2-3lbs back pressure
Again with the flick of this switch and my right foot to the boards I can bury both my pyros.
Towing is 100% dependent on your tunes/right foot. And to be honest the bigger the charger you go with, the more towing becomes driving around the trucks needs.
10k behind an s475 and your either cruising at 1000* with 1psi boost or doing 80mph to pass someone, again tuning is a huge role in smoke/egts. But keep in mine if your looking at going as big as a 4202 you will have to make some sacrifices.
I stated earlier if you want the best of all worlds (and I know shortbus will agree) its very hard to beat a 250/100s and an H2E/s366 or gt38r setup. It will put you around 500hp and tow more then the truck was ever designed for, while still spooling fast and keeping reasonable temps (again right foot dependent) as well as depending on your cab configuration, lifted or not can net you high 12s in the 1/4