The HP turbo will not grenade from high back pressure...
Think about it.
The exhaust from the HP turbo is no longer going out to the atmosphere. (0 positive pressure)
It is feeding the primary...and it takes heat, volume, and pressure to drive the primary.
So, for an example, say you have 100 psi drive pressure going into the HP turbo, and on the outlet of the exhaust, you had 50 psi...that is only a 50 psi differential across the HP turbo.
If it was a single turbo application, and had the same 100 psi drive into the turbo, and it was going straight out the exhaust...now you have pretty much the full 100 psi differential across the turbo. (minus whatever is consumed from the turbo to drive it.)
The better flow you can get through the entire engine, manifolds, turbo piping, intake etc, makes for a far more efficient system overall.