Think of a power curve (pressure spike) that starts low and travels upward and peaks then drops down like a nice bell curve.
1) Diesel is a slow burning fuel and a "soft and slow" propagation like the curve on the right.
2) Now add nitrous and the combination will "flash" (burn) at a much quicker rate and higher "explosive" pressures like the curve on the left.
Peak cylinder pressure, peak power from fuel is moved to the left which happens "sooner" (advancing the timing) so the "timing" that you programmed for fuel only is altered.
Picture is just an example to graphically show the difference.