First off, to say its a fact that a compound set up is the set up that really should have pistons or a bottom end is a little far fetched. Pistons cracking on these trucks is about the most random failure these trucks have. There is no rhyme or reason as to why these pistons crack, and is most likely a defect in the production process. There are plenty of compound set ups running around with stock motors. And if you think your stock pistons are any safer on a stock turbo set up, or on your single set up, then I'm not really sure what you have been reading. People are so quick to jump on the band wagon after they see issues on this site. You need to remember, people post on forums because they have issues, and its a great place to find information, and informative people who can help. There are way more trucks running around that don't have piston issues, then ones that do. Also, a lot of piston failures I've seen, also have signs of valve contact or injector failure.
Im not saying there is anything wrong with a single set up, but this is a thread where the OP is wondering why people on are the single turbo kick, and I'm just throwing my opinion out there. But who says it has to be a large compound set up. You can mate a 60 and 75 together and have a really responsive low budget compound set up that is relatively reliable on a stock engine.
What ever someone decides, it shouldn't be because of the sounds its makes, or because its "different". I can tell you that probably no one in a 300 mile radius has a 6.4 that can touch mine, or has a set up like mine, so its different.... But thats not why I did it. I did it because its a street truck, and I wanted big, clean power and awesome spool up. They should make the decision on what they want to do with the truck and their budget.
Austin, you pull and what not. If you put compounds like mine on your truck, you are going to be limited to basically the unlimited class in the pulls around here, which unless you have a dedicated pull truck with the driveline and suspension set up to pull, you probably wont be competitive in, regardless if you have big power, hence the reason why I don't even contemplate pulling with mine. So I understand where you are coming from.
Black Pearl. Im sure your set up is really clean and fun to drive, and I'm not sure what other trucks you've ridden in. But if you haven't ridden in a moderately sized compound truck, I'd urge you to.... You probably wont be saying that you'd do it the same way all over again....

because its amazing haha. On the other hand, if you have your single 66, you have a good base to add some fuel and stick a turbo in front of the 66, which I have to add, is a really nice benefit about these single turbo set ups, is the ability to expand off of it down the road.
Each set up has its advantages. I saved for 3 years to have what I have on my truck, and its still not where I want it. If these single kits were available back when I first bought my 08, who knows maybe I would've jumped on it since it was cheap and I wouldn't have had to wait so long to make good power. But after seeing videos of larger single set ups, and knowing how well mannered my truck is, and seeing Morgans truck with the 63mm making 10lbs just cruising, I wouldn't trade the drive-ability for a single,
especially the size single I'd need to make the same power I am right now.
On Edit: Mike beat me to the being able to expand point, which is a pretty good one....