Budget and use of the truck are really important in threads like this because you can get to the 750+ hp range a handful of ways but depending on how you use it, and how much your willing to spend will dictate what direction to go... For example a big single and tons of fuel will run a whole lot different than some compounds and relatively small injectors. Both will get you there but road manors, heat, and other abilities will be slightly different
Me personally... Typical motor work (studs, maybe upgrades valvetrain/seats) Every airflow mod available(intercooler, all the pipes, ported intake, steedspeed manis, custom bigass up pipes, huge intake and a set of compounds) , low pressure fuel system, dual fuelers, relatively small injectors, and a built tranny would be a smokeless reliable beast...